Detalhe da pesquisa
1.
Structural basis of Rho-dependent transcription termination.
Nature
; 614(7947): 367-374, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36697824
2.
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol Cell
; 69(5): 828-839.e5, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29478808
3.
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol Cell
; 72(2): 263-274.e5, 2018 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30244835
4.
Structural and mechanistic basis of σ-dependent transcriptional pausing.
Proc Natl Acad Sci U S A
; 119(23): e2201301119, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653571
5.
RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc Natl Acad Sci U S A
; 117(11): 5801-5809, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32127479
6.
Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli.
J Biol Chem
; 297(6): 101404, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34774797
7.
Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Angew Chem Int Ed Engl
; 61(45): e202211498, 2022 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222275
8.
X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc Natl Acad Sci U S A
; 114(31): 8211-8216, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652344
9.
Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J Biol Chem
; 293(35): 13616-13625, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991593
10.
Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol Microbiol
; 103(6): 1034-1045, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009073
11.
Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J Biol Chem
; 289(35): 24549-59, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24973216
12.
Structural basis of RfaH-mediated transcription-translation coupling.
bioRxiv
; 2023 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37986937
13.
Structural basis of archaeal FttA-dependent transcription termination.
bioRxiv
; 2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37609354
14.
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
J Med Chem
; 65(6): 4481-4495, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35175750
15.
Structural basis of transcription-translation coupling.
Science
; 369(6509): 1359-1365, 2020 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32820061
16.
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice.
ACS Infect Dis
; 6(10): 2573-2581, 2020 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886885
17.
Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.
Biochim Biophys Acta Gene Regul Mech
; 1861(8): 731-742, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012465
18.
Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.
SLAS Discov
; 22(3): 287-297, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28027449
19.
X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
J Med Chem
; 58(7): 3156-71, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25798859
20.
The presence of an RNA:DNA hybrid that is prone to slippage promotes termination by T7 RNA polymerase.
J Mol Biol
; 426(18): 3095-3107, 2014 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24976131